Siemens Lab
Temperature Detection and Thermoregulation

Join the Siemens Lab!

 

– POSTDOCTORAL POSITION AVAILABLE –

Establishing a novel hypothermia model in pigs

 

We are looking for an enthusiastic postdoctoral candidate (Dr. vet./med. or Ph.D.) with an experimental background using the pig as a model system.

The Siemens-lab is based at the Department of Pharmacology of the Heidelberg University (http://www.siemenslab.de/) and supported by ERC funding. We are using multidisciplinary approaches to elucidate molecular and cellular mechanisms of temperature detection and core body thermoregulation.

This particular project is supported by the Volkswagenstiftung (https://www.volkswagenstiftung.de/) and geared to probe the possibility to induce a low-temperature, “hibernation-like” state in a large animal model (pigs).

Recent progress by others and us has allowed the identification and manipulation of thermostat cells in the CNS of the laboratory mouse and activation of these discrete hypothalamic neurons in vivo triggers a low-temperature state (down to 27°C body temperature) that is completely reversible.

By manipulating the central thermostat in pig brains, this project aims to test whether it is possible to induce “hibernation-on-demand” in pigs, which – if translatable to humans – would potentially have a positive impact on trauma emergency care, among other putative applications.

Relevant Publications are:

The project would initially run for 1,5 to 2 years. Starting date would be flexible (January to May 2018).

For more information about our research group see: http://www.siemenslab.de/

Interested candidates should send CV, research background and names of one or two referees to:

jan.siemens@pharma.uni-heidelberg.de