Siemens Lab
Temperature Detection and Thermoregulation

Peripheral temperature detection and pain signal processing

We also have become interested in somatosensory processing at the level of the spinal cord. In particular, a molecular-genetic screen has guided us to study energy-metabolic requirements that accompany spinal signal processing, in particular long-lasting and strong (chronic) pain signals. Our data suggest that spinal plasticity that results as a consequence of long-lasting/strong pain signals require energetic fuel that is provided by spinal glia cells. We are currently dissecting this energetic glia-neuro coupling and hope that (pharmacological) uncoupling could provide a therapeutic angel to counteract pain chronicity.