Siemens Lab
Temperature Detection and Thermoregulation

Publications

Kamm G B, Boffi J C, Zuza K, Nencini S, Campos J, Schrenk-Siemens K, Sonntag I, Kabaoğlu B, AbdEl Hay M, Schwarz Y, Tappe-Theodor A, Bruns D, Acuna C, Kuner T, Siemens J
A synaptic temperature sensor for body cooling
2021, Neuron. Oct 20; Volume 109, Issue 20: 3283-3297
Ambroziak W, Siemens J
TRPM4 keeps up the pace
2021, Cell Calcium, ahead of print 102402, ISSN 0143-4160, https://doi.org/10.1016/j.ceca.2021.102401
Wahis J, Baudon A, Althammer F, Kerspern D, Goyon S, Hagiwara D, Lefevre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, Da Silva Gouveia M, Benusiglo D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann H S, Kirchner M K, Roy R K, Wang H, Pertin M, Pitzer C, Siemens J, Gouman Y, Boutrel B, Lamy C M, Decostered I, Chatton J-Y, Rouach N, Young W S, Stern J E, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents
2021, Nature Neuroscience doi: 10.1038/s41593-021-00800-0. Online ahead of print
Schrenk-Siemens K, Pohle J, Rostock C, Abd El Hay M, Lam R M, Szczot M, Lu S, Chesler A T, Siemens J
HESC-derived sensory neurons reveal an unexpected role for PIEZO2 in nociceptor mechanotransduction
2019, 23 August preprint doi: https://doi.org/10.1101/741660
Siemens J, Kamm G B
Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center
2018, Plügers Archiv-European Journal of Physiology, 479 (5): 8208-8222, 2018
Rostock C, Schrenk-Siemens K, Pohle J, Siemens J
Human vs. Mouse Nociceptors - Similarities and Differences
2018, Neursoscience 387, 13-27
Song K, Wang H, Kamm G, Pohle J, de Castro Reis F, Heppenstall P, Wende H, Siemens J
TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
2016, SCIENCE 23 Sep, Vol. 353, Issue 6306, pp. 1393-1398.
Wang H, Siemens J
TRP ion channels in thermosensation, thermoregulation and metabolism.
2015, Temperature, 2:2, 178-187, DOI:10.1080/23328940.2015.1040604.
Hanack C, Moroni M, Lima W, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich H, Gassmann M, Roggenkamp D, Bettler B, Lewin G, Selbach M, and Siemens J
GABA Blocks Pathological but Not Acute TRPV1 Pain Signals
2015, Cell 160, 759-770
Schrenk-Siemens K, Wende H, Prato V, Song S, Rostock R, Loewer A, Utikal J, Lewin G, Lechner S & Siemens J
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors
2015, Nature Neuroscience 18, 759-770
Milenkovic N, Zhao WJ, Walcher J, Albert T, Siemens J, Lewin GR, Poulet JF
A somatosensory circuit for cooling perception in mice
2014, Nature Neuroscience, 17 (11): 1560-66
Siemens J and Hanack C
Modulation of TRP Ion Channels by Venomous Toxins
2014, Mammalian Transient Receptor Potential (TRP) Cation Channels – Handbook of Experimental Pharmacology, Vol.223, pp1119-1142
Kapp K, Siemens J, Häring H-U, Lammers R
Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE
2012, Eur J Cell Biol, 91, 687-693
Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Müller U
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions
2002, Proc Natl Acad Sci U S A. Nov 12;99(23):14946-51
Lechner S, Siemens J
Sensory transduction, the gateway to perception: mechanisms and pathology
2011, Embo Reports, 12, 292-295
Bohlen C, Priel A, Zhou S, King D, Siemens J and Julius D
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
2010, Cell, 141, 834-845
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM
TRPA1 mediates formalin-induced pain
2007, Proc Natl Acad Sci U S A. Aug 14;104(33):13525-30
Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007, Proc Natl Acad Sci U S A. Aug 14;104(33):13519-24
Bautista D M, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D
The menthol receptor TRPM8 is the principal detector of environmental cold
2007, Nature. Jul 12;448(7150):204-8. Epub 2007 May 30
Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006, Nature. Nov 9;444(7116):208-12
Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U
Cadherin 23 is a component of the tip link in hair-cell stereocilia
2004, Nature. Apr 29; 428 (6986):950-5