Siemens Lab
Temperature Detection and Thermoregulation

Publications

Siemens J, Kamm G.B.
Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center
27 January 2018, European Journal of Physiology
Rostock C, Schrenk-Siemens K, Pohle J, Siemens J
Human vs. Mouse Nociceptors - Similarities and Differences
2018, Neursoscience (article in press)
Song K, Wang H, Kamm G, Pohle J, de Castro Reis F, Heppenstall P, Wende H, Siemens J
TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.
2016, SCIENCE 23 Sep, Vol. 353, Issue 6306, pp. 1393-1398.
Wang H, Siemens J.
TRP ion channels in thermosensation, thermoregulation and metabolism.
2015, Temperature, 2:2, 178-187, DOI:10.1080/23328940.2015.1040604.
Hanack C, Moroni M, Lima W, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich H, Gassmann M, Roggenkamp D, Bettler B, Lewin G, Selbach M, and Siemens J.
GABA Blocks Pathological but Not Acute TRPV1 Pain Signals.
2015, Cell 160, 759-770.
Schrenk-Siemens K, Wende H, Prato1 V, Song S, Rostock R, Loewer A, Utikal J, Lewin G, Lechner S & Siemens J
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
2015, Nature Neuroscience 18, 759-770.
Milenkovic N, Zhao WJ, Walcher J, Albert T, Siemens J, Lewin GR, Poulet JF
A somatosensory circuit for cooling perception in mice.
2014, Nature Neuroscience, 17 (11): 1560-66
Siemens J and Hanack C
Modulation of TRP Ion Channels by Venomous Toxins
2014, Mammalian Transient Receptor Potential (TRP) Cation Channels – Handbook of Experimental Pharmacology, Vol.223, pp1119-1142
Kapp* K, Siemens* J, Häring H-U, Lammers R.
Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE
2012, Eur J Cell Biol, 91, 687-693.
Lechner S, Siemens J.
Sensory transduction, the gateway to perception: mechanisms and pathology.
2011, Embo Reports, 12, 292-295.
Bohlen C, Priel A, Zhou S, King D, Siemens* J and Julius* D.
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain.
2010, Cell, 141, 834-845.
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM.
TRPA1 mediates formalin-induced pain.
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
Trevisani M*, Siemens J*, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P.
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24.
Bautista DM*, Siemens J*, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D
The menthol receptor TRPM8 is the principal detector of environmental cold.
Nature. 2007 Jul 12;448(7150):204-8. Epub 2007 May 30.
Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D
Spider toxins activate the capsaicin receptor to produce inflammatory pain.
Nature. 2006 Nov 9;444(7116):208-12.
Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U.
Cadherin 23 is a component of the tip link in hair-cell stereocilia.
Nature. 2004 Apr 29;428(6986):950-5.
Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Müller U.
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14946-51.